Xi'an Quanao Biotech Co., Ltd.
Tofacitinib Citrate Powder,Cas 540737-29-9 Powder,Tofacitinib Citrate 540737-29-9
Unit Price: | 16~170 USD |
---|---|
Payment Type: | T/T,L/C,D/P,D/A,Paypal,Others |
Incoterm: | DDP,CIP,CPT,FCA,CIF,EXW,CFR,FOB,DDU,Express Delivery,DEQ,DAF,DES |
Min. Order: | 1 Kilogram |
Model No.: Tofacitinib Citrate
Brand: quanao
MOQ: 1 Kg
Particle Size: 100% Pass 80 Mesh
Shelf Life: 2 Years
Appearance: White Powder
Specification: 98%
Test Method: HPLC
Product Name: Tofacitinib Citrate
CAS: 540737-29-9
Ingredients: Tofacitinib Citrate
Source: Tofacitinib Citrate
Packaging: packed in: 1kg with double plastic container inside/Aluminum foil bag outside. 25kg with double plastic container inside/Fiber drum outside.
Productivity: 50T/Month
Transportation: Ocean,Land,Air,Express,Others
Place of Origin: China,xi'an
Supply Ability: 50T/Month
Certificate: organinc,halal,iso
HS Code: 391239000
Port: Shanghai,Ningbo,Tianjin
Payment Type: T/T,L/C,D/P,D/A,Paypal,Others
Incoterm: DDP,CIP,CPT,FCA,CIF,EXW,CFR,FOB,DDU,Express Delivery,DEQ,DAF,DES
Active Pharmaceutical Ingredients Tofacitinib citrate is our product and tofacitinib is without citrate, a potent inhibitor of JAK3 (Janus kinase 3) with some JAK1 inhibitory activity as well. JAK3 blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity, Medicine Raw Material.
Tofacitinib Citrate Powder Cas 540737-29-9
[Product Name]: Tofacitinib Citrate
[Apperance]: White Powder
[Specification]: 98%
[Test Method]: HPLC
[Storage]: Store in a cool, dry place and sealed container.
Tofacitinib citrate is an oral drug used for treating rheumatoid arthritis. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune response that causes the pain, tenderness and swelling of inflammation. JAKs are found in many cells, especially stem cells in bones and joints. Inhibition of JAKs by tofacitinib prevents inflammation and tissue destruction that is associated with the inflammation of rheumatoid arthritis.
Tofacitinib (formerly tasocitinib, CP-690550) is a drug being investigated by Pfizer for the treatment of rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection. It is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.
Our Hot Sales products are: Guanfacine HCL, Isoniazid 99%, Deoxycholic Acid, Tetrahydrocurcumin and so on.
Product Categories : Active Pharmaceutical Ingredients > Anti-Rheumatism Ingredients